Brad Fittler and Wayne Bennett have both confirmed their 21-man squads for Wednesday night's crucial State of Origin clash in Sydney.
The big news is Game I stars Boyd Cordner, Cameron Murray and AJ Brimson have all been ruled out for the series following injuries suffered in the opening clash in Adelaide.
Meanwhile, nib Newcastle Knights prop Daniel Saifiti has been named to start in the front row for the Blues, while Edrick Lee and Hymel Hunt both missed out on spots in the Queensland backline.
Lee remains a chance of playing after being named in jersey No.21 on Queensland's extended bench.
The Maroons have been bolstered by the return of Valentine Holmes, who slots into the side in place of Brimson.
Meanwhile, Luke Keary has been dropped from the NSW team, with Cody Walker elevated to the starting side.
James Tedesco will take the captaincy for the Blues in Cordner's absence, while fullback contender Dale Finucane, Isaah Yeo, Junior Paulo and Nathan Brown make up a new-look bench.
FULL SQUADS
New South Wales
1. James Tedesco (c)
2. Daniel Tupou
3. Clint Gutherson
4. Jack Wighton
5. Josh Addo-Carr
6. Cody Walker
7. Nathan Cleary
8. Daniel Saifiti
9. Damien Cook
10. Payne Haas
11. Angus Crichton
12. Tyson Frizell
13. Jake Trbojevic
Interchange:
14. Dale Finucane
15. Junior Paulo
16. Nathan Brown
17. Isaah Yeo
Reserves:
18. Luke Keary
19. Reagan Campbell-Gillard
20. Cam McInnes
21. Stephen Crichton
Queensland
1. Valentine Holmes
2. Xavier Coates
3. Kurt Capewell
4. Dane Gagai
5. Phillip Sami
6. Cameron Munster
7. Daly Cherry-Evans (c)
8. Dunamis Lui
9. Jake Friend
10. Josh Papalii
11. Felise Kaufusi
12. Jaydn Su'A
13. Tino Fa’asuamaleaui
Interchange:
14. Ben Hunt
15. Lindsay Collins
16. Jai Arrow
17. Moeaki Fotuaika
Reserves:
18. Brenko Lee
19. Corey Allen
20. Josh Kerr
21. Edrick Lee
