nib Newcastle Knights coach Nathan Brown has confirmed his side to face the Rabbitohs at ANZ Stadium.
Kurt Mann will move into fullback in place of Kalyn Ponga who has been rested following State of Origin on Wednesday.
Mason Lino comes into the halves in place of Mann.
David Klemmer has been ruled out of the match due to a wrist injury.
Pasami Saulo joins the bench and will play his first NRL game for the year.
6. Kurt Mann, 2. Edrick Lee, 3. Hymel Hunt, 4. Jesse Ramien, 5. Shaun Kenny-Dowall, 21. Mason Lino, 7. Mitchell Pearce, 16. James Gavet, 9. Connor Watson, 10. Daniel Saifiti, 11. Lachlan Fitzgibbon, 12. Mitch Barnett, 13. Tim Glasby. Interchange: 14. Jamie Buhrer, 15. Herman Ese'ese, 19. Pasami Saulo, 17. Sione Mata'utia