Kalyn Ponga has been ruled out of game three of the State of Origin series.
The nib Newcastle Knights fullback has suffered a lateral hamstring strain.
The Grade 1+ injury will keep Ponga sidelined for 3-4 weeks.
Meanwhile, Slade Griffin's season is over.
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The No.9 has suffered multiple ruptures to ligaments in his knee.
The injury to Griffin includes a ruptured ACL graft, ruptured lateral ligament and torn lateral meniscus.
He will undergo an ACL reconstruction in the coming weeks.
Griffin will undergo 9-12 months of rehab.
Injury setback; Brown addresses Ponga and Griffin condition
Injured players and expected return dates:
Tautau Moga (ACL, Season)
Slade Griffin (Knee, Season)
Jacob Saifiti (Shoulder, Round 24)
Kalyn Ponga (Hamstring, Round 20-21)
Daniel Saifiti (Foot, Round 18-19)
Mitchell Pearce (Pectoral, Round 18-19)