Kalyn Ponga and Anthony Milford have been called into the Queensland squad ahead of the Holden State of Origin series opener.
The news comes after Billy Slater confirmed he will not play in the Melbourne Cricket Ground blockbuster due to a hamstring injury.
"I didn't pull up as well as I would have liked after our training run on Sunday, and because I'm not 100 per cent, it's in my best interests as well as the team's to withdraw from Wednesday's game," Slater said.
Maroons coach Kevin Walters will consult with selectors and senior players before deciding on the final make-up of the side closer to kick off.
"We knew we had some concerns with Billy, but he's a champion player and we needed to give him every chance to play," Walters said.
"We've had plans in place to cover Billy if he didn't come up right, and we've actioned that today with Anthony and Kalyn coming in."
