The NSW Blues have made seven changes from the 17 they named for the opening game of the series, including naming two debutants in Melbourne's Dale Finucane and Newcastle's Daniel Saifiti.
James Maloney is back in sky blue following an afternoon of drama that saw Mitchell Pearce ruled out of Origin II through injury.
Injuries to David Klemmer and Payne Haas has forced a reshuffle in the forward pack, with Tariq Sims also called back into the team to replace Roosters back-rower Angus Crichton.
Blake Ferguson has also earned a recall to the Blues.
NSW team
1. James Tedesco
2. Blake Ferguson
3. Tom Trbojevic
4. Jack Wighton
5. Josh Addo-Carr
6. James Maloney
7. Nathan Cleary
8. Daniel Saifiti
9. Damien Cook
10. Paul Vaughan
11. Boyd Cordner (c)
12. Tyson Frizell
13. Jake Trbojevic
14. Dale Finucane
15. Tariq Sims
16. Cameron Murray
17. Wade Graham