It's at the business end of the season with both the Knights' Harold Matthews and Tarsha Gale squads progressing to the preliminary finals.
It's do or die for both teams, with wins securing a spot in the deciders.
Fresh and ready to go, the U16s have had the week off after progressing straight through to the pre-lims.
Jonah Pezet is named back in the no. 7 after being ruled out in their semi-final. He'll pair with Taj Blackman in the halves which sees Mitch Henderson drop to the bench.
Charlie Thompson, who injured himself in the trials, comes in for Sean Walker who suffered a dislocated shoulder.
1. Chris Veaila, 2. Brody Perry, 3. Travis Petersen, 4. Fletchers Myers, 5. Charlie Thompson, 6. Taj Blackman, 7. Jonah Pezet, 8. Noah Reed, 9. Noah Nailagoliva, 10. Angus Crosbie, 11. Max Bradbury, 12. Oryn Keeley, 13. Lachlan Crouch. Interchange. 14. Mitch Henderson, 15. Jacob Davis, 16. Taj Ridley, 17. Macauley Aoake, 22. Riley Cullen, 23. Beau Dwyer.
Saturday, 27th April - Newcastle Knights v Penrith Panthers at St Mary's Leagues stadium - 12pm
It was a gallant effort against last years premiers, the Cronulla Sharks on Good Friday, to see the girls progress through to week three of finals.
An almost unchanged squad this week with just a few switches in the forward pack this week.
1. Jorja Holden, 2. Ashlee Russell, 3. Petria Symington, 4. Jasmin Strange, 5. Carissa Harrison, 7. Joeli Morris, 8. Kayla Romaniuk, 9. Bree O'Neill, 10. Cody Campbell, 11. Olivia Kernick, 12. Caitlan Johnston. Interchange. 13. Tanaya Millar, 14. Zoe Coyne, 16. Ella Buteux, 17. Lily Hanning, 18. Terri-Lee Van Wyk, 25. Naydine Wahanui.
Saturday, 27th April - St George Illawarra Dragons v Newcastle Knights at St Mary's Leagues stadium - 10.30am