Coach Nathan Brown has finalised his side to take on the Panthers in Round 4, with a number of changes and an NRL debutant.
Pete Mata'utia shifts to fullback, with younger brother Sione Mata'utia taking his place in the centres alongside Nathan Ross.
Luke Yates moves into the second row for Sione Mata'utia, while 2017 recruit Joe Wardle (Player #284) is set to make his NRL debut from the bench.
Having played the first three rounds of the season in reserve grade on his comeback from off-season knee surgery, Wardle will provide utility value at either centre or second row.
Josh King and Jacob Gagan drop off the extended bench.
The match kicks off at 6pm.
Newcastle
4. Peter Mata'utia, 2. Ken Sio, 3. Dane Gagai, 11. Sione Mata'utia, 5. Nathan Ross, 6. Brock Lamb, 7. Trent Hodkinson, 8. Daniel Saifiti, 9. Danny Levi, 10. Josh Starling, 14. Luke Yates, 12. Jamie Buhrer, 13. Mitch Barnett. Interchange: 15. Jack Stockwell, 16. Sam Stone, 17. Jacob Saifiti, 19. Joe Wardle.
Penrith
1. Matt Moylan, 2. Dean Whare, 3. Waqa Blake, 4. Tyrone Peachey, 5. Dallin Watene-Zelezniak, 6. Te Maire Martin, 7. Nathan Cleary, 8. James Tamou, 9. Peter Wallace, 10. Reagan Campbell-Gillard, 21. Corey Harawira-Naera, 12. Isaah Yeo, 13. Trent Merrin. Interchange: 14. Peta Hiku, 15. Leilani Latu, 16. Viliame Kikau, 17. Sitaleki Akauola.
